The big guy/little guy partnership has been used repeatedly in cartoons. When my sons were little, the TV cartoon that used this trope most obviously was Pinky and the Brain. The cartoon focused on two genetically enhanced laboratory mice who resided in a cage inside the Acme Labs research facility. Brain, the littler of the two mice, was highly intelligent, self-centered and scheming. Pinky was Brain’s sweet-natured but feeble-minded henchman. In every episode, Brain devised a new plan to take over the world, but his plans always failed, with hilarious results.
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